In 1995 the Chamber inaugurated a Gulf States Chapter in Tampa and Northeast Chapter in Monterrey. Later the same year Mexico’s Ambassador to the United States, His Excellency Jesús Silva-Herzog, also an Honorary President, opened the Northwest Chapter, with offices in Seattle. Ambassador Jones and Sen. Miguel Aleman inaugurated new offices for a Mexico City Chapter in February 1996.
In 1997, the Chamber inaugurated its Great Lakes Chapter, headquartered in Detroit and the Inter-American Chapter in Miami. In 1998, through a strategic alliance with the National Chamber of Commerce of Guadalajara, the Chamber established the Pacífico Chapter-Guadalajara in that city.
In 1999, the Governor of the State of Aguascalientes, Felipe González and CANACINTRA-Aguascalientes opened new offices for the Pacífico Chapter in Aguascalientes. In the year 2000, President Vicente Fox, former Governor of the State of Guanajuato, inaugurated the Bajío Chapter in León, Guanajuato. In 2001, Governor Tommy Thompson of Wisconsin and Governor Jesse Ventura of Minnesota were opening offices of the Chamber in Milwaukee and Minneapolis respectively. The Mid-West Chapter started operations in Milwaukee in 2002 while the Minneapolis Office is in organization. In 2002, the Governor of the State of Veracruz, Miguel Alemán, inaugurated the Golfo Chapter at the Port of Veracruz. In 2007 the Chamber opened Chapter offices in three strategic locations within Mexico: Puebla, Cancun, and Querétaro. In 2008 the Las Vegas Chapter in Nevada, the Southeast Chapter in North Carolina and the Fort Worth Chapter in Texas were inaugurated. Currently, the Michoacán Chapter in Morelia and the Yucatán Chapter in Mérida, are currently in the process of being organized.
To further promote stronger bilateral relations, the Chamber established the U.S.-Mexico Cultural and Educational Foundation in 1996. The foundation, a 501 (c) (3) non-profit organization, oversees educational and cultural exchanges designed to develop business leaders of the future, infuse practical business knowledge into the academic realm and foment understanding between the neighboring countries.